pI: 8.3063 |
Length (AA): 231 |
MW (Da): 27717 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
97 | 128 | 2e50 (A) | 28 | 62 | 31.00 | 0.84 | 0.03 | 0.367328 | -0.16 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | gametocyte, merozoite, sporozoite, early ring, early trophozoite, late ring, late schizont, late trophozoite, Ring, Female Gametocyte, Male Gametocyte. | PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, early schizont. | Otto TD PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 32 hs, Oocyst. | Otto TD Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Sporozoite. | Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. | Otto TD |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Ortholog group members (OG5_127581)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_IV008890 | cytochrome c/c1 heme lyase, putative |
Babesia bovis | BBOV_III011500 | cytochrome c/c1 heme lyase, putative |
Brugia malayi | Bm1_07670 | cytochrome C-type heme lyase |
Candida albicans | CaO19.1957 | cytochrome c heme lyase similar to S. cerevisiae CYC3 (YAL039C) |
Candida albicans | CaO19.12047 | cytochrome c1 heme lyase |
Candida albicans | CaO19.4578 | cytochrome c1 heme lyase |
Caenorhabditis elegans | CELE_T06D8.6 | Protein CCHL-1 |
Dictyostelium discoideum | DDB_G0275895 | cytochrome c heme-lyase |
Drosophila melanogaster | Dmel_CG6022 | Cytochrome c heme lyase |
Echinococcus granulosus | EgrG_000965700 | cytochrome c type heme lyase |
Echinococcus multilocularis | EmuJ_000965700 | cytochrome c type heme lyase |
Homo sapiens | ENSG00000004961 | holocytochrome c synthase |
Loa Loa (eye worm) | LOAG_08710 | cytochrome C-type heme lyase |
Mus musculus | ENSMUSG00000031352 | holocytochrome c synthetase |
Neospora caninum | NCLIV_000340 | hypothetical protein |
Neospora caninum | NCLIV_057230 | cytochrome c heme lyase, putative |
Plasmodium berghei | PBANKA_1439500 | cytochrome c heme lyase |
Plasmodium berghei | PBANKA_0602600 | cytochrome c1 heme lyase |
Plasmodium falciparum | PF3D7_1224600 | cytochrome c heme lyase, putative |
Plasmodium falciparum | PF3D7_1203600 | cytochrome c1 heme lyase, putative |
Plasmodium knowlesi | PKNH_1443900 | cytochrome c heme lyase, putative |
Plasmodium knowlesi | PKNH_1303400 | cytochrome c1 heme lyase, putative |
Plasmodium vivax | PVX_084225 | cytochrome c1 heme lyase, putative |
Plasmodium vivax | PVX_123860 | cytochrome c heme lyase, putative |
Plasmodium yoelii | PY05914 | cytochrome c1 heme lyase |
Saccharomyces cerevisiae | YKL087C | cytochrome c1 heme lyase CYT2 |
Saccharomyces cerevisiae | YAL039C | holocytochrome c synthase CYC3 |
Schistosoma japonicum | Sjp_0011050 | ko:K01764 cytochrome c heme-lyase [EC4.4.1.17], putative |
Schistosoma mansoni | Smp_022320.1 | cytochrome C1 heme lyase |
Schistosoma mansoni | Smp_022320.2 | cytochrome C1 heme lyase |
Schmidtea mediterranea | mk4.003317.04 | |
Schmidtea mediterranea | mk4.006193.00 | Probable cytochrome c-type heme lyase |
Schmidtea mediterranea | mk4.004164.00 | |
Schmidtea mediterranea | mk4.011512.02 | |
Toxoplasma gondii | TGME49_314042 | cytochrome c1 heme lyase, putative |
Toxoplasma gondii | TGME49_293390 | cytochrome C-type heme lyase, putative |
Theileria parva | TP02_0784 | cytochrome c heme lyase, putative |
Theileria parva | TP01_0886 | cytochrome c1 heme lyase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_T06D8.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T06D8.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T06D8.6 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_1439500 | Plasmodium berghei | Essential | plasmo |
TGME49_293390 | Toxoplasma gondii | Probably essential | sidik |
TGME49_314042 | Toxoplasma gondii | Probably essential | sidik |
TGME49_293390 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_314042 | Toxoplasma gondii | Essentiality uncertain | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.